Illustration of SpaceOAR Hydrogel
Physician's Perspective

Outcomes and Efficiencies with an Iodinated Hydrogel Spacer

Sean Collins, MD
Radiation Oncologist, Georgetown University Hospital
Still from Video.

Outcomes and Efficiencies with an Iodinated Hydrogel Spacer

Sean Collins, MD, PhD
Radiation Oncologist, Georgetown University Hospital

Dr. Collins has been using the Boston Scientific SpaceOAR™ Hydrogel since 2016.

Sean Collins, MD, is a Boston Scientific consultant and was compensated for his contribution to this editorial. Statements made represent the opinion and experience of Dr. Collins. Results from case studies are not necessarily predictive of results in other cases. Results in other cases may vary.


Editorial Commentary




As a radiation oncologist, I use multiple strategies in my practice to mitigate long-term rectal toxicity in prostate cancer patients. One patient, a doctor himself, with ulcerative colitis, approached me about six years ago requesting that I treat his cancer and that I use a SpaceOAR Hydrogel spacer as part of his treatment. This request was the impetus for bringing it into my practice. Since then, I’ve found that using a rectal spacer—specifically an iodinated spacer (SpaceOAR Vue™ Hydrogel)—provides numerous advantages, including improved contouring accuracy, which helps to reduce the radiation dose delivered to the rectum, thus minimizing impact to the rectum. 1-3  

In my experience with rectal spacers, the hydrogel and soft tissues, such as the prostate and rectum, have similar radiodensities. This sometimes makes it difficult to visualize on a CT scan, thus making contouring more challenging. For optimal delineation of critical tissues, a treatment planning MRI is suggested. Image registration and fusion of the CT scan and MRI is inherently challenging, which can lead to uncertainties in the gel interface with the prostate and rectum. 

However, when using an iodinated spacer, I have found that the iodine makes it easier to differentiate the prostate and the rectum making the fusion of the MRI and CT scans more straightforward. An iodinated rectal spacer such as the SpaceOAR Vue, is readily visible on a CT scan and this improves target coverage, particularly posterior target coverage, which in turn helps us ensure reduced radiation dose delivered to the rectum.1 In my practice, I have also found SpaceOAR Vue is easy to place with a low chance of clogging the needle, and the absorption profile is approximately six months. 

Contouring Approach

Every radiation oncologist contours in their own way. I believe it's more of an art than a science. But, in my opinion, there’s no question that contouring the prostate precisely is a critical step during treatment with radiation therapy.4 Proper contouring can lead to better patient outcomes by reducing the chance of rectal toxicity.

When my team is treating a patient with Stereotactic Body Radiation Therapy (SBRT), the first step is putting gold markers in the prostate simultaneously with the SpaceOAR Vue placement. The second step is getting a treatment planning MRI and a treatment planning CT scan and fusing them together. Then I take those scans and program the computer to administer the dose to the prostate without overdosing the rectum, the bladder and the penis. 

I’ve contoured approximately 2,000 patients over the past 15 years. With first generation, non-iodinated spacers, I needed about 60 minutes for contouring, which included entering targeting details in the computer. However, now that I am using the SpaceOAR Vue in my practice, I have found that it improves visibility on CT, thus simplifying the fusion process and making it more efficient. It has also cut our contouring process time in half—maybe even more—and has reduced the fusion inaccuracy.1 It’s also important to note that, because the gel is iodinated, the SpaceOAR Vue can be seen on cone beam CT when aligning the patient within the radiation machine during daily treatment.1

Dose Escalation and Contraindications

The optimal rectal dose constraints for patients with a rectal spacer undergoing conventional fractionated radiotherapy, moderately hypofractionated radiotherapy or SBRT are currently unknown. I believe that, at a minimum, typical dose constraints used in non-spacer patients should be easily achievable with placement of a spacer and should allow for safer dose escalation. At least that has been my experience. One frequently employed strategy I use to aggressively manage rectal dose is to contour the spacer itself as part of the rectal contour.

Since iodinated rectal spacers are readily visible on a CT scan, I have found in my practice that this allows for improved delineation of target volumes and organ at risk (OAR) dose calculations. But if image registration and fusion are even slightly off, it could lead to uncertainties in the gel interface with the prostate and rectum, as well as inaccuracies in target and OAR dose calculations. 

The SpaceOAR Vue is particularly helpful for patients who are unable to get a treatment planning MRI, due to implanted metallic devices.1 Contouring without an MRI can be very challenging and increases the likelihood of under-dosing the prostate or overdosing the rectum. However, when there is an iodinated spacer between the prostate and the rectum, I find it’s easier to delineate the rectum, the spacer and the prostate which, again, is essential for correct dosing.1 

However, if there is a presence of posterior extracapsular extension between the prostate and the rectum, I would not consider using SpaceOAR Vue. But this is uncommon in most patients. 

Patient Outcomes and Insights

While, in general, long-term survival rates are excellent in prostate cancer patients treated with definitive radiotherapy,  some patients do experience late effects of radiotherapy that can be difficult to manage.6 The data suggests that the use of a spacer helps minimize bowel side effects in these patients.3 And in my practice, we’ve very clearly seen the additional benefit of improved quality of life when using a hydrogel spacer, and particularly the iodinated hydrogel spacer.1,2

My team is very thorough about following up with all 2,000 of my patients. We inquire about subtle details—such as the unexpected urge to use the bathroom. We want to know about anything that impacts their quality of life. Being able to track their experience, even when it includes toxicity, has been essential in helping me refine my practice to ensure patients are getting the best care. In fact, I continue to follow up with the doctor who requested I treat him with a spacer and I'm happy to say that he's doing well. He's six years out from treatment now. His PSA is very low and he’s had no undue side effects. He’s very happy with that outcome and I'm grateful that his request resulted in me helping hundreds of other patients in similar situations. 


While contouring is very much a personal approach for physicians, I’ve found that contouring with an iodinated spacer makes my job easier. In my experience, contouring with an iodinated spacer provides both physicians and patients with benefits, including improved accuracy during contouring, saving my time, all while minimizing impact of radiation on the rectum.


Related Content



asset image

SpaceOAR Vue Whitepaper

Authored by Washington University School of Medicine physicians, Randall J. Brenneman and Brian C. Baumann, this clinical whitepaper demonstrates how SpaceOAR Vue Hydrogel can offer enhanced visibility on CT scans and workflow advantages. 

Read the whitepaper

Still from video. Dr. Fredman slide

Dr. Elisha Fredman video

Dr. Elisha Fredman from the Davidoff Cancer Center and Rabin Medical Center in Petah Tikva, Israel shares his clinical experience with SpaceOAR Hydrogel Systems in his prostate cancer therapy approach.

Hear Dr. Fredman's conclusions

Still from video. Dr. Collins sitting in an interview setting discussing late rectal toxicity

Dr. Collins late rectal toxicity video

Dr. Sean Collins, Radiation Oncologist, discusses how SpaceOAR Hydrogel can help reduce late rectal toxicity in patients following radiation therapy.

Watch the video

Indications, safety and warnings

Follow on Twitter

Stay up to date on the latest happenings.


Get SpaceOAR Hydrogel

Become a certified applier.


Sign Up

Get exclusive updates and clincial data.