Investigator-Sponsored Research Program

The Investigator-Sponsored Research (ISR) Program represents an important portion of medical research. The ISR Program serves as a conduit between Boston Scientific and external researchers to expand research.

Boston Scientific provides support for research that advances medical and scientific knowledge about our products and that generates medical interventions. This global program is open to all qualified researchers who are interested in conducting their own research

SUBMIT A GRANT REQUEST

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ASK A QUESTION

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Research Areas

Each Boston Scientific division reviews research requests for a variety of topics pertaining to Boston Scientific products and associated disease states.

We are currently looking at research in the following areas:

Cardiovascular

Endoscopy/Pulmonary

Neuromodulation

Rhythm & Electrophysiology, incl. Cardiac Rhythm Management

Urology and Pelvic Health

Cardiovascular Topics of Interest

New/emerging Technologies
New/extended applications of DES
Role of DES in extended patient groups
Health Economics and/or Quality of Life
Comparative-Effectiveness
Geographic variation in device use
Valvular disease

Rhythm & Electrophysiology Topics of Interest

Cardiac mapping
Cardiac ablation
Subcutaneous ICD
Heart failure
Left atrial appendage closure

Endoscopy/Pulmonary Topics of Interest

Gastro
Biliary
Snares
polypectomy
Severe asthma and bronchial thermoplasty (BT)
- BT – patient selection and markers of response and/or safety.
- Severe asthma – natural history.
Bronchial thermoplasty in practice
- Case studies demonstrating safety and efficacy of BT.
- Procedure optimization.
- Clinical experience in patients with characteristics such as:
  - Low FEV1
  - Elderly
  - Occupational asthma
  - Allergic and non-allergic asthma
  - Asthma with concomitant use of immunomodulatory agents
  - Asthma with a COPD component.
- Patient satisfaction data.
- Clinical outcome data such as impact on medication usage.
Bronchial thermoplasty mechanism of action
- Evaluate the impact of BT on airway remodeling, inflammation, and hyperresponsiveness.
- Assess impact on asthma pathophysiology.
- Identification of biomarkers for patient responders
- Further definition of patient responders.

Urology and Pelvic Health Topics of Interest

Upper Tract Stone Disease
- Optimal laser settings for dusting vs. fragmentation and associated stone free rates
- Endoscope – flexible ureteroscope - economics – single use versus reusable (repair costs, deterioration of performance, safety, etc.)
- Stent encrustation (causes, effects on patients, economic impact, patient and economic costs of forgotten indwelling stents)
- Ureteral stent pain
BPH
- Use of GreenLight XPS™ PVP Laser System in men with prostate volume > 80 grams
- Use of GreenLight XPS PVP Laser System in men that are high risk surgical candidates i.e. anticoagulated
- Comparison of GreenLight XPS PVP Laser System with other surgical modalities for BPH (Plasma Button, HoLep, Thulium)
- Economic data regarding the health system costs of Green Light XPS Laser System compared to other treatments for BPH
Female Stress Urinary Incontinence
- The case for minislings as standard of care therapy for stress urinary incontinence: Solyx™ SIS System versus TVT™ Retropubic System
- White paper on requirements for moving minislings into the office: clinical and re-imbursement perspectives
Pelvic Floor Reconstruction
- Randomized study on distal support of the anterior vaginal compartment utilizing the Uphold ™LITE Vaginal Support System with and without concomitant anterior wall plication
- Safety and efficacy outcomes following treatment of apical and anterior vaginal compartment with the Uphold LITE transvaginal mesh system and with abdominal sacrocolpopexy
- Predictors of repair durability in treatment of anterior vaginal compartments with the Xenform™ extra cellular matrix
Abnormal Uterine Bleeding
- Comparisons of different treatment modalities on patient outcomes and post-procedural complications (i.e. pain)
- Assess impact of vasopressin and mean arterial pressure on fluid management
Removal of Uterine Tissue (Fibroids, Polyps)
- Data on efficacy and safety
- Comparative studies with currently available technologies
- Data on the cost effectiveness of Symphion™ Tissue Removal System for polyps and fibroids
Male Stress Urinary Incontinence
- Predictors of urethral atrophy after AUS placement
- Long-term outcomes for AUS placement after pelvic XRT
- Validation of a questionnaire to assess the severity of male SUI to show correlation to treatment options
Male Erectile Dysfunction
- Patient satisfaction in men receiving an IPP for ED (flaccid state, rigidity, penile girth)
- Cost effectiveness of IPP as first line therapy in men with ED and a poor prognosis for the success of conservative therapies

Neuromodulation Topics of Interest

Spinal Cord Stimulation
- Treatment of chronic, intractable pain of the back and legs using the Spectra WaveWriter™ SCS System
  - Of particular interest:
    - Efficacy of combination therapy
    - Programming optimization
    - Contour™ field shaping algorithm vs other field shapes
    - Anatomical vs paresthesia-based neural targeting
Deep Brain Stimulation
- Treatment of Parkinson’s Disease and other movement disorders using Vercise™ Deep Brain Stimulation System
  - Of particular interest:
    - Freezing of gait
    - Replacement of other DBS systems with Vercise DBS System
    - Use of multiple frequencies on one lead
    - Use of current fractionalization to maximize overlap with desired structures and minimize stimulation of non-target tissue
    - Novel targets for Parkinson’s Disease, Dystonia, Tremor (may require IDE)

How the U.S. Physician Payment Sunshine Act Impacts Sponsored Researchers

The U.S. Physician Payment Sunshine Act requires all pharmaceutical, biologic and medical device manufacturers – like Boston Scientific – to report annually to the U.S. government payments and transfers of value made to U.S. physicians and teaching hospitals. This could include educational and research grants and charitable donations.

Read additional details about the U.S. Physician Payment Sunshine Act

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