Grade 2+ GI toxicity or rectal bleeding across reported trials
“Use of rectal hydrogel spacer for prostate proton beam therapy is associated with significantly lower incidence of clinically relevant, late rectal bleeding and lower decrement in long-term, patient-reported bowel QOL compared with rectal balloon immobilization. Our results suggest that hydrogel spacer may improve rectal sparing compared to rectal balloon immobilization during proton beam therapy for prostate cancer.”
- Dinh TKT, Lee Jr HJ, Macomber MW, et al. Rectal hydrogel spacer improves late gastrointestinal toxicity compared to rectal balloon immobilization after proton beam radiation therapy for localized prostate cancer: a retrospective observational study. Int J Radiat Oncol Biol Phys. 2020 Nov 1;108(3):635–43.
PBT was not the method used in the SpaceOAR™ Hydrogel single-blind Phase III trial performed to evaluate dosimetric and clinical effects of SpaceOAR Hydrogel. IG-IMRT delivered at 79.2 Gy in 1.8-Gy fractions was the method used.
Results from case studies are not necessarily predictive of results in other cases. Results in other cases may vary.
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