EkoSonic™ Endovascular System

Ultrasonic Technology

Control Unit

Clinical Evidence

Key Resources

EkoSonic Indications, Safety, and Warnings

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The Acoustic Pulse Difference

Acoustic Pulse Thrombolysis is a minimally invasive system for dissolving thrombus. The ultrasonic core generates an acoustic field which greatly accelerates lytic dispersion by driving the drug deeper into the clot and unwinding the fibrin to expose plasminogen receptor sites.

Acoustic Pulse Thrombolysis

Is a minimally invasive system for dissolving thrombus.

The ultrasonic core generates an acoustic field which greatly

accelerates lytic dispersion by driving the drug deeper into the

clot and unwinding the fibrin to expose plasminogen receptor sites.

2014	2015
ULTIMA	SEATTLE II
n=59, Confirmed EKOS was superior to AC alone in RV/LV reduction without an increase in bleeding, Prospective RCT: Level 1	n=150, Prospective Confirmed EKOS improved RV function, pulmonary hypertension, and clot burden without an increase in bleeding

2014

2015

ULTIMA

SEATTLE II

n=59, Confirmed EKOS was superior to AC alone in RV/LV reduction without an increase in bleeding, Prospective RCT: Level 1

n=150, Prospective
Confirmed EKOS improved RV function, pulmonary hypertension, and clot burden without an increase in bleeding

2018	2021
OPTALYSE	KNOCOUT
n=101, Provided lower doses & infusion times for the treatment of acute PE without an increase in bleeding, Prospective, Long-Term & QOL	n=1,500, Retrospective & Prospective. Patient registry to understand APT treatment protocols & show effects on LT outcomes

2018

2021

OPTALYSE

KNOCOUT

n=101, Provided lower doses & infusion times for the treatment of acute PE without an increase in bleeding, Prospective, Long-Term & QOL

n=1,500, Retrospective & Prospective. Patient registry to understand APT treatment protocols & show effects on LT outcomes

EKOS' targeted ultrasound waves accelerate thrombus dissolution by unwinding the fibrin matrix.¹

The Thrombus Barrier

Tightly wound fibrin prevents lyticfrom reaching receptor sites.

With Acoustic Pulse

Ultrasonic energy thins fibrinand exposes receptor sites.

With Acoustic Pulse + Lytic

More drug reaches entire thrombus,accelerating absorption.

1. Braaten JV et al. Ultrasound reversibly disaggregates fibrin fibers.Thromb Haemost 1997;78:1063-8

5.4 F infusion catheter for all EKOS products

Product	Working Length	Treatment Zone
500-55106	106 cm	6 cm
500-55112	106 cm	12 cm
500-55118	106 cm	18 cm
500-55124	106 cm	24 cm
500-55130	106 cm	30 cm
500-55140	106 cm	40 cm
500-55150	106 cm	50 cm
500-56112	135 cm	12 cm
500-56130	135 cm	30 cm
500-56140	135 cm	40 cm
500-56150	135 cm	50 cm

106cm long, 0.035 inch guidewire compatible and one ultrasonic core matched to infusion length.

135cm long, 0.035 inch guidewire compatible and one ultrasonic core matched to infusion length.

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