The Acoustic Pulse Difference

Acoustic Pulse Thrombolysis is a minimally invasive system for dissolving thrombus. The ultrasonic core generates an acoustic field which greatly accelerates lytic dispersion by driving the drug deeper into the clot and unwinding the fibrin to expose plasminogen receptor sites.

Acoustic Pulse Thrombolysis

Is a minimally invasive system for dissolving thrombus.

The ultrasonic core generates an acoustic field which greatly

accelerates lytic dispersion by driving the drug deeper into the

clot and unwinding the fibrin to expose plasminogen receptor sites.
Acoustic Pulse

 

 

2014

2015

ULTIMA

SEATTLE II

n=59, Confirmed EKOS was superior to AC alone in RV/LV reduction without an increase in bleeding, Prospective RCT: Level 1

 

n=150, Prospective
Confirmed EKOS improved RV function, pulmonary hypertension, and clot burden without an increase in bleeding

 

2018

2021

OPTALYSE

KNOCOUT

n=101, Provided lower doses & infusion times for the treatment of acute PE without an increase in bleeding, Prospective, Long-Term & QOL

 

n=1,500, Retrospective & Prospective. Patient registry to understand APT treatment protocols & show effects on LT outcomes

 

 

EKOS' targeted ultrasound waves accelerate thrombus dissolution by unwinding the fibrin matrix.1

Fibrin before treatment
The Thrombus Barrier
Tightly wound fibrin prevents lyticfrom reaching receptor sites.
Fibrin with Acoustic Pulse
With Acoustic Pulse
Ultrasonic energy thins fibrinand exposes receptor sites.
Fibrin with Acoustic Pulse + Lytic
With Acoustic Pulse + Lytic
More drug reaches entire thrombus,accelerating absorption.
1. Braaten JV et al. Ultrasound reversibly disaggregates fibrin fibers.Thromb Haemost 1997;78:1063-8

 

5.4 F infusion catheter for all EKOS products

Product Working Length Treatment Zone
500-55106 106 cm 6 cm
500-55112 106 cm 12 cm
500-55118 106 cm 18 cm
500-55124 106 cm 24 cm
500-55130 106 cm 30 cm
500-55140 106 cm 40 cm
500-55150 106 cm 50 cm
500-56112 135 cm 12 cm
500-56130 135 cm 30 cm
500-56140 135 cm 40 cm
500-56150 135 cm 50 cm

106cm long, 0.035 inch guidewire compatible and one ultrasonic core matched to infusion length.

135cm long, 0.035 inch guidewire compatible and one ultrasonic core matched to infusion length.

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