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Renal Cell Carcinoma (RCC)​

Learn about kidney (renal) cancer and treating with cryoablation.

 

Being diagnosed with kidney (renal) cancer can be an incredibly stressful time, but medical advances mean that today, the chances of you beating the disease are better than ever before. Historically, the only option was surgery to remove either the whole kidney (nephrectomy) or the part of the kidney where the tumor was located (partial nephrectomy). Now, there are treatments available which require only small incisions or none at all.

What is renal cancer?

Renal cell carcinoma (RCC) is also called renal or kidney cancer. Kidney cancer is among the 10 most common cancers in both men and women.1 RCC is more commonly found in men between the ages of 50-70 but can be diagnosed in anyone. The number of people being diagnosed with kidney cancer is increasing, but it has been suggested that this is due to more tumors being identified during routine scans and better testing, rather than more people getting kidney cancer. After being diagnosed with kidney cancer, your physician will determine if it has spread (and if so, how far) using a process called staging. This will help your physician understand the best options to treat the cancer. ​

The kidneys are bean-shaped organs, each about the size of an adult fist.1 Most people have two kidneys located in the lower back, one on either side of the spine. ​

The main job of the kidneys is to filter blood coming in from the renal arteries to remove excess water, salt, and waste products.1 These substances are then excreted from the body in the form of urine. ​

The kidneys also help control blood pressure and make sure the body has enough red blood cells.1

Knowing the symptoms

icon of exclamatory

Kidney cancer doesn’t typically cause symptoms at first. 

Over time, the following symptoms may develop:​
  • Blood in urine​
  • Feeling tired or having no energy​
  • Lump or swelling in your back, under your ribs, or in your neck​
  • Pain between your waist and ribs that doesn’t go away​
  • A high temperature that doesn’t go away​
  • Loss of appetite

Treating kidney cancer with cryoablation​

Cryoablation uses extremely cold temperatures to create ice that physicians can shape or sculpt to engulf and kill the tumor2,3 while preserving surrounding tissues. For patients who are suitable for cryoablation, it offers many benefits, including:​

  • Over 25 years of published data supporting its safety and effectiveness2
  • Similar results compared to surgery in smaller tumors
  • Proven effectiveness in treating 95% of targeted renal tumors3-6
  • Preserves renal function by protecting healthy tissue7-8
  • A minimally invasive option: ​
    • Small to no incisions ​
    • Low complication rate with minimal discomfort5,9-11
    • Excellent recovery time, with short or no hospital stay and rapid return to normal activities5,8,12

 

  • May be suitable for ​
    • Multiple and small tumors5,8,11
    • Large tumors (up to 7 cm) where surgery is not recommended6,8,10 ​
    • Repeat treatments (after previous cryotherapy or after another procedure such as surgery)13,14
    • Tumors positioned close to structures which might risk being damaged with other types of treatment8,9,12,15,16

Real world results

Data shows cryoablation provides clinically similar outcomes compared to other standard treatments for kidney cancer, including partial nephrectomy and radiofrequency ablation.17 For T1a masses under 4 cm, differences between partial nephrectomy and cryoablation treatments are not likely. Treatment choice should be discussed with your physician.

graph showing oncologic outcomes for t1a and t1b patients at 5yrs.

Overall, cryoablation may be associated with longer overall survival compared with heat-based thermal ablation in T1a RCC under 4 cm.18

graph showing Kaplan-Meier survival estimates of cryoablation versus heat-based ablation treatment. Kaplan-Meier Survival Estimates - 1

How it works

Understand how cryoablation targets and destroys kidney cancer

Understanding a cryoablation treatment

How long does a procedure take?​

Although each case is different, using the percutaneous approach typically lasts one to two hours while a laparoscopic kidney cryoablation procedure usually takes between two-and-a-half to three hours. ​

How will I feel after the procedure?​

Often patients are asked to take it easy for one to two days after the procedure, but many return to normal activity the next day. ​

How long will I need to stay at the hospital?​

Length of stay will vary by patient and procedure. Typically, patients will be discharged the day of the procedure, however some physicians may prefer their patients to stay for at least one night after a cryoablation procedure. ​

Will insurance cover this procedure?​

Consult your insurance carrier to find out the specific criteria for coverage. The reimbursement specialist at your physician’s office may also be able to help you with this.​

 

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References

1. American Cancer Society. What is Kidney Cancer? Jan 2019 ​

2. Kunkle DA, Uzzo RG. Cancer 2008; 113(10): 2671-80 ​

3. Rodriguez R, Cizman Z, Hong K et al. Cardiovasc Intervent Radiol 2011; 34: 573-8 ​

4. Guazzoni G, Cestari A, Buffi N et al. Urology 2010; 76: 624-9 ​

5. Georgiades CS, Rodriguez R. Cardiovasc Intervent Radiol 2014; 37(6): 1494-9 ​

6. Atwell TD, Callstrom MR, Farrell MA et al. J Urol 2010; 184: 1291-5 ​

7. Lucas SM, Cadeddu JA. J Endourol 2010; 24(5) doi.org/10.1089/end.2009.0442 ​

8. Buy X, Lang H, Garnon J et al. Am J Roentgenol 2013; 201(6): 1353-61 ​

9. Allaf ME, Varkarakis IM, Bhayani SB et al. Radiology 2005; 237(1): 366-70 ​

10. Breen DJ, Bryant TJ, Abbas A et al. BJU Int 2013; 112: 758-65 ​

11. Yan X, Zhang M, Chen X et al. W J Surg Oncol 2015; 13: 200 ​

12. Littrup P, Ahmed A, Aoun H et al. J Vasc Interv Radiol 2007; 18: 383-92 ​

13. Okhunov Z, Chamberlin J, Moreira DM. J Endourol 2016 Jun; 30(6): 632-7 ​

14. Morgan MA, Roberts NR, Pino LA et al. Can J Urol 2014; 20(5): 6933-7 ​

15. Rosenberg MD, Kim CY, Tsivian M et al. Am J Roentgenol 2011; 196: 935-9 ​

16. Park SH, Kang SH, Yo YH et al. Korean J Urol 2010; 51(8): 518-24​

17. Andrews JR, Atwell T, Schmit G, Lohse CM, et al. Eur Urol. 2019; 76(2):244-251

18. Wu J, Chang J, Bai, HX et al. J Vasc Interv Radiol 2019; 30(7): 1027-33e3