Why Paclitaxel
Boston Scientific chose paclitaxel for AGENTTM Drug-Coated Balloon (DCB) by design – delivering higher drug transfer1, and proven durability where it matters most.
Boston Scientific accounts are for healthcare professionals only.
AGENT achieves higher acute drug transfer.1
The AGENT difference:
Paclitaxel is hydrophobic
Paclitaxel has greater durability during delivery for minimized drug loss.2
Paclitaxel is lipophilic
Paclitaxel’s higher affinity to fatty tissue results in rapid drug absorption.2
Sharp-edge structure
AGENT’s needle-like coating improves tissue penetration.3
AGENT with Paclitaxel has improved tissue penetration.3
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References:
1. DCB pre-clinical testing performed by Boston Scientific Corporation. Data-on-file at BSC. In several independent studies, AGENT and Selution DCB were delivered to different coronary arteries. Treated vessel segments were analyzed at one-hour for drug concentration.
2. Surapaneni, M., et al. "Designing Paclitaxel drug delivery systems aimed at improved patient outcomes: current status and challenges." International Scholarly Research Notices (2012).
3. Chang, G., et al. Scientific Reports 9.1 (2019): 6839
4. Böhme, T., Noory, E., Beschorner, U., Macharzina, R., & Zeller, T. (2020). The Selution SLRTM drug-eluting Balloon Systemf or the Treatment of Symptomatic Femoropopliteal Lesions. Future Cardiology, 17(2), 257–267. https://doi.org/10.2217/fca-2020-0085
Please review the AGENT Brief Summary for full instructions on use.