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AGENT Drug-Coated Balloon

MODERN PCI - Treat

Right Drug.
Right Design.

Why AGENT

Boston Scientific chose paclitaxel for AGENT™ Drug-Coated Balloon (DCB) by design – delivering higher drug transfer,1 and proven durability where it matters most compared to sirolimus or ‘limus-based DCBs that have shown less drug durability1 and less use on DCBs worldwide.

90% of Coronary DCBs Worldwide use Paclitaxel2

Here’s why.

Global use isn't a coincidence - it's a clinical consensus. 90% coronary DCBs use paclitaxel. AGENT uses the world's most trusted DCB drug.

Before treatment even begins, does the drug survive the trip?

Drug delivery begins before inflation. In pre-clinical tracking models, AGENT maintained coating integrity during delivery, while Selution SLR demonstrated visible coating loss prior to device inflation.5

Examine DCB drug coating durability post-tracking, pre-inflation.*

SELUTION SLR™ DEB Sirolimus Drug pre-tracking.
SELUTION SLR™ DEB Sirolimus Drug Post-tracking.

SELUTION SLR™ DEB

Sirolimus Drug
AGENT™ DCB Paclitaxel Drug pre-tracking.
AGENT™ DCB Paclitaxel Drug post-tracking.

AGENT™ DCB

Paclitaxel Drug

AGENT with Paclitaxel has improved tissue penetration.6

AGENT: Sharp-edge Paclitaxel.

High tissue penetration

AGENT: Sharp-edge Paclitaxel6

‘Limus DCB: Spherical structure.

Low tissue penetration

‘Limus DCB: Spherical structure7

The AGENT difference

Paclitaxel is hydrophobic,

Paclitaxel is hydrophobic

Paclitaxel has greater durability during delivery for minimized drug loss.1

Paclitaxel is lipophilic​

Paclitaxel is lipophilic​

Paclitaxel’s higher affinity to fatty tissue results in rapid drug absorption.1

Sharp-edge structure.

Sharp-edge structure

AGENT’s needle-like coating improves tissue penetration​.6

AGENT achieves higher acute drug transfer​.3

Agent transferred 2.3x more drug into the tissue acutely.
Average acute drug transfer in a pre-clinical model (ng/mg).

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References:

1. Surapaneni, M., et al. "Designing Paclitaxel drug delivery systems aimed at improved patient outcomes: current status and challenges." International Scholarly Research Notices (2012).

2. The Business Research Company - Drug-Coated Balloons Global Market Report: https://www.thebusinessresearchcompany.com/report/drug-coated-balloons-global-market-report

3. DCB pre-clinical testing performed by Boston Scientific Corporation. Data-on-file at BSC. In several independent studies, AGENT and Selution DCB were delivered to different coronary arteries. Treated vessel segments were analyzed at one-hour for drug concentration.

4. Surapaneni, M., et al. "Designing Paclitaxel drug delivery systems aimed at improved patient outcomes: current status and challenges." International Scholarly Research Notices (2012).

5. Data on file. 

6. Chang, G., et al. Scientific Reports 9.1 (2019): 6839

7. Böhme, T., Noory, E., Beschorner, U., Macharzina, R., & Zeller, T. (2020). The Selution SLRTM drug-eluting Balloon System for the Treatment of Symptomatic Femoropopliteal Lesions. Future Cardiology, 17(2), 257–267. https://doi.org/10.2217/fca-2020-0085

*Each device was evaluated individually using a downstream particulate bench test designed to replicate physiological blood flow. Pre‑tracking images show coating before use; post‑tracking images show devices after simulated guide‑catheter tracking, prior to inflation. Bench Test results may not necessarily be indicative of clinical performance. The testing was performed by Boston Scientific. Data on file.

Selution SLR™ is an investigational device and is limited by U.S. law to investigational use.