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SEISMIQ™ 4CE ​ Coronary Intravascular Lithotripsy Catheter​.

SEISMIQ™ 4CE Coronary Intravascular Lithotripsy Catheter​

CAUTION: Investigational device. Limited by US law to investigational use only. Not available for sale. ​

SEISMIQ 4CE (pronounced 'force') is a novel intravascular lithotripsy catheter used in patients undergoing PCI for the treatment of coronary artery disease with severely calcified lesions. This product is currently being evaluated for safety and efficacy in the FRACTURE IDE Trial. ​

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Intravascular lithotripsy (IVL)

Intravascular lithotripsy (IVL) is a catheter‑based therapy designed to treat patients with calcified coronary artery disease. IVL delivers acoustic pressure waves inside a balloon to fracture hardened calcium, restore vessel compliance, and enable effective lesion preparation prior to definitive therapy, such as treating with a stent.​

Laser‑based IVL takes traditional IVL a step further. By using focused laser energy and a quad-emitter design to generate acoustic pressure waves within the balloon, SEISMIQ 4CE is designed to deliver precise, consistent calcium modification—helping physicians prepare complex lesions with greater control while minimizing the need for high-pressure dilation.

IVL in calcium morphologies:​

Severe Concentric Calcium​

Coronary artery showing severe concentric calcium.

Eccentric Calcium

Coronary artery showing eccentric calcium.

Nodular Calcium

Coronary artery showing nodular calcium.

Looking for information on our SEISMIQ Peripheral IVL Catheter?

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Image of peripheral SEISMIQ Intravascular Lithotripsy Catheter.

Discover the Modern PCI approach

Image artwork of OPTICROSS™ HD Coronary Imaging Catheters.

See the vessel

Assess plaque type and severity using the latest imaging and physiology technology. Eliminate guesswork and make clearer treatment decisions.

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Image artwork of WOLVERINE coronary cutting balloon product demonstrating quality vessel preparation.

Prep the vessel

Successful outcomes start with proper lesion assessment and vessel preparation. Achieve optimal lumen gain with our cutting balloon and rotational atherectomy tools.

Explore vessel prep
Image artwork of AGENT drug-coated balloon demonstrating reliable and efficient drug transfer for vessel treatment.

Treat the vessel

With our innovative stent portfolio and coronary drug-coated balloon technology, you have access to market-leading therapies that will ensure you are able to improve long-term patient outcomes.

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Product details

SEISMIQ is a new coronary Intravascular Lithotripsy (IVL) System - an advanced laser-based​ platform that is designed to deliver consistent acoustic output to treat a broad range of calcified lesions.

A SEISMIQ shift in calcium modification

Image of peripheral SEISMIQ Intravascular Lithotripsy Catheter.

SEISMIQ 4CE is designed for: 

Icon of arrow circling 360 degrees.

360° of Impact

4 Coronary Emitters (4CE) deliver uniform acoustic pressure in all directions for consistent results

Icon of lightening bolt.

Advanced Therapy

Increased available therapy (pulses) to maximize the usability of each catheter in all types of calcified procedures

Icon of deliverability.

Deliverability

Deliverability when it matters most with low crossing profiles, robust pushability and trackability

Icon of eye.

Visibility

Visible, directional emitters with on/off selectivity to direct energy to concentric, eccentric, and nodular calcium lesions

Clinical highlights

FRACTURE IDE Trial​

The FRACTURE IDE Trial aims to assess the safety and efficacy of SEISMIQ 4CE, a novel intravascular lithotripsy catheter, in patients undergoing PCI for the treatment of coronary artery disease with severely calcified lesions. 

The FRACTURE IDE Trial has completed enrollment, and clinical data will be shared here after it is released at EuroPCR on May 19, 2026.

CAUTION: SEISMIQ 4CE is an investigational device. Limited by US law to investigational use only. Not available for sale. ​

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