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Intera 3000™ Hepatic Artery Infusion Pump

The Intera 3000 HAI Pump is an FDA-approved, implantable pump used to treat tumors in the liver from colorectal cancer liver metastases (CRLM) and intrahepatic cholangiocarcinoma (iCCA).

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A powerful liver-directed treatment for patients with CRLM and iCCA

HAI therapy exposes tumors in the liver to up to 400x greater drug concentration than systemic infusion while minimizing systemic exposure.1

The HAI pump continuously perfuses the entire liver, allowing patients to maintain their quality of life.2

 

1. Ensminger WD, Gyves JW. Semin Oncol. 1983;10(2):176-8
2. Ensminger WD, et al. Cancer Res. 1978;38(11 Pt 1):3784-92. 

Ordering information


Product Number

Material Description

Unit of Measure

AP-03000H 

Hepatic Artery Infusion Pump 

Each

AP-07014US 

HAI Pump Refill Kit 

Each

AP-07004

HAI Pump Operating Room Prep Kit

Each

AP-04030 

Non-Coring Refill Needle, 2 IN, 15PK 

Box - 15

AP-04013-5 

Special Bolus Needle, 1 3/8 IN, 5PK 

Box - 5

AP-04032-5 

Special Bolus Needle, 2 IN, 5PK 

Box - 5

IP-37957 

HAI Tapered Catheter 

Each

81643-9270-1 

FLOXURIDINE FOR INJECTION, USP 

Each

From clinical summaries and data presentation templates, to patient education and program support, we are committed to helping support your HAI Therapy program.

 


View HAI instructions for use and other resources. HAI resource portal


Program support

Resources designed to support institutions providing HAI therapy


Clinical data

Clinical summary series: HAI Therapy for CRLM and iCCA

Long-term outcomes in patients with advanced intrahepatic cholangiocarcinoma treated with hepatic arterial infusion chemotherapy

Cowzer D et al. 2024

Taken together, results of the prospective phase II study and retrospective analysis of routine clinical care underscore the ability of HAI to achieve durable long-term disease control and prolonged survival in patients with advanced, unresectable iCCA.


Clinical summary series: HAI Therapy for CRLM and iCCA

Hepatic arterial infusion pump chemotherapy in patients with unresectable intrahepatic cholangiocarcinoma—PUMP-2 trial

Franssen S, et al. 2025

A multicenter trial from the Netherlands—the PUMP-2 study—has shown remarkable survival benefits for patients with unresectable intrahepatic cholangiocarcinoma (iCCA) confined to the liver. 


Clinical summary series: HAI Therapy for CRLM and iCCA

Combined hepatic arterial infusion pump and systemic chemotherapy in the modern era for chemotherapy-naïve patients with unresectable colorectal liver metastases

Verheij FS, et. al., 2023

This single-center retrospective cohort study showed that chemotherapy-naïve patients with unresectable colorectal liver metastases (CRLM) who received HAI + systemic chemotherapy had a high rate of conversion to resection or complete response, which was associated with prolonged survival.


Clinical summary series: HAI Therapy for CRLM and iCCA

Hepatic arterial infusion pump chemotherapy for unresectable intrahepatic cholangiocarcinoma: a systematic review and meta-analysis

Holster JJ, et. al., 2022

This systematic review of 9 publications demonstrated HAI was associated with substantial improvement in survival for unresectable intrahepatic cholangiocarcinoma (iCCA) patients.

From treatment journey guides and patient FAQs, to appointment checklists and educational videos, these resources are designed to support  conversations with patients and caregivers about HAI Therapy.

 

Patient resources

Comprehensive patient resources covering HAI Therapy and living with the Intera 3000™ HAI Pump.


Patient testimonials

Real patients. Real results. Learn how HAI Therapy has helped patients reclaim their lives.

HAI therapy: Patient medley video

Hope's story: Stage 4 colorectal cancer

Marsha's story: Stage 4 colon cancer

Rick's story: Bile duct cancer survivor

Thomas' story: Stage 4 colorectal cancer


Patient animation

Watch how the Intera 3000(tm) HAI Pump delivers treatment directly to tumors in the liver.

What is HAI therapy?

JND Therapeutics, Inc. is the U.S. distributor of Floxuridine for Injection, USP. Floxuridine for Injection, USP is for intra-arterial infusion only.