Clinical Effectiveness of DBS for Dystonia
Key Resources
| Primary Author | Study Design | Sample Size | Follow Up | BFMDRS or TWSTERS | Change in Mean Scores BFMDRS or TWSTERS | % Improvement in BFMDRS and TWSTERS |
Cersosimo et al, 2009¹ | Prospective Case Series | 9 | 6 mos. | BFMDRS (Motor Scale) | • Baseline: 46.9 ± 24.3 • Post DBS: 24.1 ± 16.9 | Not Reported |
Houeto et al, 2007² | Prospective, Controlled, Multicenter | 22 | 1 mo. | BFMDRS (Motor Scale) | • Baseline: 46.3 ± 21.1 • Post DBS*: 26.7 ± 14.9 | Not Reported |
Vidailhet et al, 2005³ | Prospective, Controlled, Multicenter | 22 | 12 mos. | BFMDRS (Motor Scale) | • Baseline: 46.3 ± 21.3 • Post DBS: 21 ± 14.1 | 51 |
Vidailhet at al, 2007⁴ | Prospective, Controlled, Multicenter | 22 | 36 mos. | BFMDRS (Motor Scale) | • Baseline: 46.3 ± 21.3 • Post DBS: 19.8 ± 17.4 | 58 |
Kiss et al, 2007⁵ | Prospective, Single-Blind, Multicenter | 10 | 12 mos. | TWSTERS (Severity Score) | • Baseline: 14.7 ± 4.2 • Post DBS: 8.4 ± 4.4 | 43 |
Kupsch et al, 2006⁶ | Prospective, Controlled, Multi-center | 40 | 6 mos. | BFMDRS (Motor Scale) | • Baseline: 36.4 ± 24.6 • Post DBS: 20.2 ± 18 | 46 |
Volkmann et al, 2012⁷ | Prospective, Controlled, Multi-center | 40 | 5 yrs. | BFMDRS (Motor Scale) | • Baseline: 43.4 ± 28.6 • Post DBS: 15.4 ± 16.3 | 60 |
Ostrem et al, 2011⁸ | Prospective Pilot | 9 | 12 mos. | TWSTERS (Total Score) | • Baseline: 53.1 ± 2.57 • Post DBS: 19.6 ± 5.48 | 62.9 |
Vidailhet et al, 2009⁹ | Prospective | 13 | 12 mos. | BFMDRS (Motor Scale) | • Baseline: 44.23 ± 21.12 • Post DBS: 34.69 ± 21.87 | 24.4 |
- Cersosimo MG, Raina GB, Benarroch EE, Piedimonte F, Aleman GG, & Micheli FE. “Micro lesion effect of the globus pallidus internus and outcome with deep brain stimulation in patients with Parkinson disease and dystonia.” Mov Disord 2009. 24(10), 1488-1493.
- Houeto JL, Yelnik J, Bardinet E, Vercueil L, Krystkowiak P, Mesnage V, Vidailhet M. “Acute deep-brain stimulation of the internal and external globus pallidus in primary dystonia: functional mapping of the pallidum.” Arch Neurol. 2007. Sep;64(9):1281-6.
- Vidailhet M, Vercueil L, Houeto JL, Krystkowiak P, Benabid AL, Cornu P, Pollak P. “Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystonia.” N Engl J Med 2005., 352(5), 459-467.
- Vidailhet M, Vercueil L, Houeto JL, Krystkowiak P, Lagrange C, Yelnik J, Pollak P. “Bilateral, pallidal, deep-brain stimulation in primary generalized dystonia: a prospective 3 year follow-up study.” Lancet Neurol 2007. 6(3), 223-229.
- Kiss ZH, Doig-Beyaert K, Eliasziw M, Tsui J, Haffenden A, Suchowersky O. “The Canadian multicenter study of deep brain stimulation for cervical dystonia.” Brain 2007, 130(Pt 11), 2879-2886.
- Kupsch A, Benecke R, Müller J, Trottenber, T, Schneider GH, Poewe W, Volkmann J. “Pallidal Deep-Brain Stimulation in Primary Generalized or Segmental Dystonia.” New Engl J Med 2006, 355(19), 1978-1990.
- Volkmann J, Wolters A, Kupsch A, Muller J, Kuhn AA, Schneider GH, Benecke R. “ Pallidal deep brain stimulation in patients with primary generalised or segmental dystonia: 5-year follow-up of a randomized trial.” Lancet Neurol 2012. 11(12), 1029-1038.
- Ostrem JL, Racin, CA, Glass GA, Grace JK, Volz MM, Heath SL, Starr PA. “Subthalamic nucleus deep brain stimulation in primary cervical dystonia.” Neurol 2011. 76(10), 870-878.
- Vidailhet M, Yelnik J, Lagrange C, Fraix V, Grabli D, Thobois S, Pollak P. “Bilateral pallidal deep brain stimulation for the treatment of patients with dystonia-choreoathetosis cerebral palsy: a prospective pilot study.” Lancet Neurol 2009. 8(8), 709-717.