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Versatile Endoscopic Closure Tools for Diverse Clinical Needs

Choosing the Right Closure

Effective closure depends on selecting the most appropriate solution for the size, depth, and location of the defect, as well as procedural intent. Selecting the right approach supports safe, effective outcomes and helps complete the resection pathway with confidence.

In higher-risk scenarios such as larger lesions, right-sided colon resections, or rectal endoscopic submucosal dissection (ESD), prophylactic closure can play a key role in reducing the risk of delayed adverse events, particularly delayed bleeding, supporting more predictable recovery and reducing the need for additional interventions or extended hospital stays.

No two procedures are the same. Partner with us for a range of products, services, and solutions that empower you to deliver the best possible care.

Our Closure Portfolio

etm simple closure

Simple Closure

Through-the-scope clips provide a reliable and efficient approach for closing many mucosal defects. Built on established workflows, they support consistent mechanical approximation across a broad range of endoscopic procedures.

Explore our TTS Clips

               

    

advanced closure

Advanced Closure

When greater strength, tissue capture, or deeper defect involvement is expected, advanced endoscopic clips and closure solutions can offer enhanced closure security and procedural versatility.

Explore our MANTIS™ Clip

Explore our X-Tack™ Closure Solutions

     

    

complex closure

Complex Closure

Our endoscopic suturing system enables physicians to manage complications in therapeutic GI procedures and provide patients with GI tract treatment in place of traditional surgery.

Explore our OverStitch NXT™

     

Why Prophylactic Closure After Resection Matters

physician in mask


Prophylactic closure of postresection defects can help reduce delayed adverse events, most notably delayed bleeding, especially in higher risk scenarios such as large lesions, right sided colon, or rectal ESD.1-3

Evidence continues to evolve, but multiple randomised and comparative studies show meaningful reductions in delayed bleeding when closure is applied selectively.4-8
 

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Real World Evidence

Reduced delayed bleeding after colorectal ESD in RCTs.1

Relative reduction in delayed bleeding.2

Real-world multicentre data show lower bleeding and fewer overnight stays.3

Prophylactic closure plays a key role in completing the resection pathway and supporting procedural consistency.

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Product catalogue​

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References

1. Miyakawa A, et al. Gut. 2025;74(11):1814-20.

2. Huang PF, et al. Surg Endosc. 2026;1-14.

3. Karna R, et al. Dig Dis Sci. 2025.

4. Yi S, Cai Q, Zhang L, et al. Association between prophylactic closure of mucosal defect and delayed adverse events after endoscopic resection: a systematic review and meta- analysis. BMJ Open 2024;14:e077822. doi:10.1136/bmjopen-2023-077822

5. Turan A.S, Pohl H, Matsumoto M, Siersema, P.D., Van Geenen, E.J.M. The Role of Clips in Preventing Delayed Bleeding After Colorectal Polyp Resection: An Individual Patient Data Meta-Analysis. Clinical Gastroenterology and Hepatology2021; 20, 362-371.e23

6. Spadaccini M, Albéniz E, Pohl H. Rex, D.K., Hassan, C., Repici, A et al Prophylactic Clipping After Colorectal Endoscopic Resection Prevents Bleeding of Large, Proximal Polyps: Meta-analysis of Randomized Trials. Gastroenterology, 2020; 159, 148-158.e11

7. Chen B, Du L, Luo L, Cen M, Kim J.J. Prophylactic clips to reduce delayed polypectomy bleeding after resection of larg colorectal polyps: a systematic review and meta-analysis of randomized trials. Gastrointestinal Endoscopy, 2020; 93, 807-815

8. Huang, PF., Chen, PJ., Huang, TY. et al. Prophylactic wound closure after ESD significantly reduces post-ESD bleeding: stratified and meta-regression analyses by tumor size and rectal proportion. Surg Endosc 40, 3914–3927 (2026). https://doi.org/10.1007/s00464-026-12622-x1.

CAUTION: The law restricts these devices to sale by or on the order of a physician. Indications, contraindications, warnings, and instructions for use can be found in the product labelling supplied with each device or at www.IFU-BSCI.com. Products shown for INFORMATION purposes only and may not be approved or for sale in certain countries. This material not intended for use in France. All images owned by Boston Scientific.