Ultrasound-assisted Thrombolysis treatment is a minimally invasive system for dissolving thrombus. Learn more how its targeted ultrasound waves accelerate thrombus dissolution.
The Acoustic Pulse Difference
Acoustic Pulse Thrombolysis is an ultrasound-assisted treatment that is a minimally invasive system for dissolving thrombus. The ultrasonic core generates an acoustic field which greatly accelerates lytic dispersion by driving the drug deeper into the clot and unwinding the fibrin to expose plasminogen receptor sites.
Acoustic Pulse Thrombolys Treatment
- Speeds time-to-dissolution.12
- Increases thrombus removal and clinical improvement compared to either standard catheter-directed therapy (CDT) or thrombectomy.1
- Lowers the risk of bleeding and other complications.1,3
More Effective Drug Delivery:
- Reduces dosage requirements by as much as 68% compared to standard CDT.3
- Requires up to 4x less drug dosage than systemic delivery.5,6
- Reduces RV/LV ratio with as little as 8mg total tPA used in combination with EKOS therapy.1
Acoustic Pulse Thrombolys Treatment
- 48% greater drug absorption within 1 hour.7
- 84% greater drug absorption within 2 hours.7

Tightly wound fibrin strands prevent lytic from reaching receptor sites

Ultrasonic energy thins fibrin strands and exposes receptor sites

More drug reaches entire thrombus, accelerating absorption
The EKOS System’s targeted ultrasound waves accelerate thrombus dissolution by unwinding the fibrin matrix.
Lower Patient Risk.
Higher Procedure Predictability.
The EkoSonic™ Endovascular System includes an ultrasonic core within an infusion catheter, and control unit.
Targeting the Thrombus, Safely
With EKOS Acoustic Pulse Thrombolysis treatment most of the drug remains in the thrombus and you can typically use less lytic. It dissolves the thrombus without damaging vessels, valves or walls.3, 9 There is no mechanical disruption resulting in distal embolisation.10 The EKOS System’s safety and efficacy is supported by Level 1 and Level 2 data.5, 6, 11, 12, 13

Reduced Procedure Time2,3
EKOS requires significantly shorter treatment times, typically only 33-50% of standard CDT. Unlike more complex surgical solutions1, 4, EKOS is an efficient, three-step process