EPOCH trial design

Interventional Oncology



Interventional Oconlogy EPOCH Trial data sheet

An international, multi-centre, open-label, phase III, randomised controlled trial to study the impact of TheraSphere™ Y-90 Glass Microspheres in combination with second-line systemic chemotherapy for colorectal liver metastases (CLM)


Trial Design

Phase III, open label, multicentre (95 sites), prospective, 1:1 randomised trial.
Primary endpoints:

  • PFS according to RECIST 1.1 from time of randomization to disease progression or death 
  • hPFS according to RECIST 1.1, from time of randomization to thedate of disease progression in the liver or death ​

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