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ClinicalEVIDENCE Newsletter

Newsletter #9 – March 2026

March Issue

Welcome to the Clinical EVIDENCE newsletter, your go-to source for clinical data and commentary on heart diseases, diagnostics, and monitoring.​

​Our aim is to deliver the very latest insights and information, so you can stay up to speed with the most recent advancements in the field of heart failure management and sudden cardiac death prevention.​

Summary

This edition of Clinical Evidence examines personalised strategies in Implantable Cardioverter Defibrillator (ICD) therapy, spotlighting the latest technologies and comparing their respective strengths and limitations in minimising complications and inappropriate shocks1. As implant rates rise, we also unpack the factors influencing longevity in subcutaneous systems (S-ICDs), as reported by Ziacchi et al.2 in their review of emerging real-world data.​

​In our third article, the INGEVITYTM+ lead is shown to achieve high implantation success, stable electrical performance, and low complication rates in left bundle branch area pacing (LBBAP).3 Finally, we turn to insertable cardiac monitors (ICMs), where advances in detection algorithms are helping to reduce false positives in the LUX-DxTM II+.4​

Key Takeaways

  • Device selection in ICD therapy: Monkhouse et al.1 advise moving beyond implantation criteria to prioritise individualised device selection.​​

  • Battery performance in modern S-ICDs: Ziacchi et al.2 conclude real-world device longevity exceeds manufacturer projections, reinforcing the need for standardised reporting criteria.​​

  • Safety and performance of INGEVITYTM+ lead for LBBAP​:3 An analysis by Santoro et al. builds on earlier evidence, further supporting the safety and reliability of the INGEVITY+ use in LBBAP implantation.​
  • Enhanced Detection Algorithms in ICMs:  Richards M. et al.4 Algorithm refinement can improve the diagnostic yield of insertable cardiac monitoring by reducing false-positive detections while maintaining sensitivity.

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References:

  1. Monkhouse C, Ahsan S, Lambiase PD. Contemporary issues in implantable cardioverter-defibrillators: Personalising device therapy. Indian Heart J. 2025 Oct 17:S0019-4832(25)00181-6. doi: 10.1016/j.ihj.2025.10.003.​​​

  2. Ziacchi M, Viani S, Bambagioni G, et al. Estimated Longevity of Contemporary Subcutaneous Implantable Cardioverter-Defibrillators: Multicenter Real-World Data. Heart Rhythm O2. doi: 10.1016/j.hroo.2026.01.020. ​​​

  3. Santoro A, Ziacchi M, Calvanese R, et al. Al Implantation Success, Electrical Performance, and Safety of an Active Fixation Stylet-Driven Lead for LBBAP in Clinical Practice: A Multicenter Experience. J Cardiovasc Electrophysiol. 2025 Dec 27. doi: 10.1111/jce.70237​.​

  4. Richards M, Kupfer M, Herrmann K et al. Algorithm Improvements in an Insertable Cardiac Monitor Reduce False Positives and Episode Review Burden. Pacing Clin Electrophysiol. 2025 Dec;48(12):1337-1343. doi: 10.1111/pace.70043.​​

CAUTION:
The law restricts these devices to sale by or on the order of a physician. Indications, contraindications, warnings, and instructions for use can be found in the product labelling supplied with each device or at www.IFU-BSCI.com. Products shown for INFORMATION purposes only and may not be approved or for sale in certain countries.
This material not intended for use in France.