KNOCOUT PE
Prospective Cohort: 3-Month Data

Importance:
With 489 patients, the prospective KNOCOUT cohort represents the largest prospective body of evidence in the interventional PE space to-date. The registry included a wide range of patients with intermediate-high and high-risk PE, making it an accurate representation of patients with PE treated with EKOS every day. In addition, KNOCOUT captures the largest breadth of contemporary clinical practices with 83 centers enrolled across the United States and Europe between 2018 and 2020.
Take-away:
Results from KNOCOUT PE reflect contemporary clinical practice and demonstrated effective treatment of PE with EKOS with lower r-tPA dose and shorter infusion duration, and low major hemorrhagic complications and zero intracerebral hemorrhagic events.