Radiofrequency Ablation - Clinical Literature Review
The safety and efficacy of biliary RFA using the Habib™ EndoHPB has been established by a growing number of publications in medical journals.
Radiofrequency Ablation & Metal Stenting
Authors: Huihong Liang, Zhenwei Peng, Liangqi Cao, Shikun Qian, Zili Shao
Date: October 2015
The sudy is a retrospective comparison of stent patency and survival of patients with unresectable extrahepatic cholangiocarcinoma (CCA) treated by placement of self-expanding metal stents (SEMS) with or without endobiliary radiofrequency ablation (ERFA).
RFA for the management of occluded biliary metal stents
Authors: Abdurrahman Kadayifci, Mustafa Atar, David G Forcione, Brenna W Casey, Peter B Kelsey, William R Brugge
Date: December 2016
This study aimed to assess the efficacy of RFA for management of occluded SEMS.
Patients with biliary malignancy and treated for an occluded SEMS were retrospectively reviewed. The study group comprised patients treated with RFA using an Habib endoprobe inside the SEMS. The control group comprised patients treated only with insertion of a plastic stent into an occluded SEMS. The end points were; 90-day stent patency rate, time to stent reocclusion, 30-day mortality, and 3 - and 6-month survival rates.
Radiofrequency ablation for ampullary neoplasms
Authors: Tarun Rustagi, Shayan Irani, D Nageshwar Reddy, Barham K Abu Dayyeh, Todd H Baron, Christopher J Gostout, Michael J Levy, John Martin, Bret T Petersen, Andrew Ross, Mark D Topazian
Date: July 2017
The study is a multicenter, retrospective analysis of all patients with intraductal extension of ampullary neoplasms treated with endoscopic RFA between February 2012 and June 2015. The feasibility, safety, and efficacy of endoscopic radiofrequency ablation (RFA) in the management of ampullary neoplasms with intraductal extension have been evaluated. Treatment success was defined as the absence of detectable intraductal polyps by ductography, visual inspection, and biopsy sampling.
Endoscopic RFA of Biliary Malignant Strictures in Pancreatic Cancer
Title: Analysis of Endoscopic RFA of Biliary Malignant Strictures in Pancreatic Cancer Suggests Potential Survival Benefit
Authors: Yiannis Kallis, Natalie Phillips, Alan Steel, Harry Kaltsidis, Panagiotis Vlavianos, Nagy Habib, David Westaby
The aim of this study retrospective case–control analysis has been to analyze the clinical efficacy of endobiliary RFA. It was carried out for 23 patients with surgically unresectable pancreatic carcinoma and malignant biliary obstruction undergoing endoscopic RFA and SEMS insertion and 46 controls(SEMS insertion alone) in a single tertiary care center. Controls were stringently matched for age, sex, metastases, ASA/comorbidities. Survival, morbidity, and stent patencyrates were assessed.
Radiofrequency Ablation on Malignant Biliary Strictures
Title: Impact of Radiofrequency Ablation on Malignant Biliary Strictures: Results of a Collaborative Registry
Authors: Reem Z Sharaiha, Amrita Sethi, Kristen R Weaver, Tamas A Gonda, Raj J Shah, Norio Fukami, Prashant Kedia, Nikhil A Kumta, Carlos M Rondon Clavo, Michael D Saunders, Jorge Cerecedo-Rodriguez, Paola Figueroa Barojas, Jessica L Widmer, Monica Gaidhane, William R Brugge, Michel Kahaleh
Date: July 2015
In this study, the safety, efficacy, and survival outcomes of patients receiving endoscopic radiofrequency ablation have been evaluated. Between April 2010 and December 2013, 69 patients with unresectable neoplastic lesions and malignant biliary obstruction underwent 98 radiofrequency ablation sessions with stenting.
Efficacy and safety of endoscopic radiofrequency ablation for unresectable extrahepatic cholangiocarcinoma
Title: Efficacy and safety of endoscopic radiofrequency ablation for unresectable extrahepatic cholangiocarcinoma: a randomized trial
Authors: Jianfeng Yang, Jing Wang, Haibin Zhou, Yifeng Zhou, Yang Wang, Hangbin Jin, Qifeng Lou, Xiaofeng Zhang
Date: August 2018
The aim of this study was to explore the clinical effect and safety of RFA in patients with unresectable extrahepatic cholangiocarcinoma. 65 patients with unresectable extrahepatic cholangiocarcinoma, except Bismuth type III and IV hilar cholangiocarcinoma, were enrolled and randomly underwent either RFA combined with biliary stenting (RFA + stent group; n = 32) or biliary stent only (stent-only group; n = 33). Overall survival time, stent patency period, and postoperative adverse events were recorded.
Radiofrequency ablation combined with biliary stent Placement versus stent placement alone for malignant biliary strictures
Title: Radiofrequency ablation combined with biliary stent Placement versus stent placement alone for malignant biliary strictures: a systematic review and meta-analysis
Authors: Aijaz Ahmed Sofi, Muhammad Ali Khan, Ananya Das, Mankanwal Sachdev, Sadik Khuder, Ali Nawras, Wade Lee
Date: April 2018
This meta-analysis is to evaluate the efficacy and safety of biliary stent placement with RFA compared with stent placement alone in patients with malignant biliary strictures. A comprehensive search of electronic databases for all studies comparing RFA with biliary stent placement versus stent placement only has been performed. Measured outcomes included patient survival, stent patency, and procedure-related adverse events. An inverse variance method was used to pool data on stent patency into a random-effects model. Cox-regression analysis was used to calculate hazard ratio for survival analysis. We used the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) framework to interpret our findings.
Radiofrequency ablation for refractory benign biliary stricture
Title: Intraductal radiofrequency ablation for refractory benign biliary stricture: Pilot feasibility study
Authors: Bing Hu, Dao-Jian Gao, Jun Wu, Tian-Tian Wang, Xiao-Ming Yang, Xin Ye
Date: July 2014
Initial experience of radiofrequency ablation (RFA) for the management of BBS. Nine patients with BBS (post operation stricture four, liver transplant three, and chronic inflammation two), seven of whom had previously unsuccessful endoscopic or percutaneous interventions, were enrolled. Intraductal bipolar RFA was delivered at power of 10 W for 90 s per stricture segment, followed by balloon dilatation with/without stent placement.
Double Radiofrequency Ablation with Metal Stent Placement for Refractory Benign Biliary and Pancreatic Duct Strictures
Title: Double Radiofrequency Ablation with Metal Stent Placement for Refractory Benign Biliary and Pancreatic Duct Strictures
Authors: Tadahisa Inoue, Rena Kitano, Kiyoaki Ito, Masashi Yoneda
Date: June 2020
As the evidence of RFA for benign biliary strictures are very limited, and the use of RFA for benign pancreatic duct strictures has not been reported, this study reports a case of double RFA combined with metal stent placement for refractory benign biliary and pancreatic duct strictures.