Clinical Evidence

ClinicalEVIDENCE Newsletter

Newsletter #8 – December 2025

December Issue

Welcome to the ClinicalEVIDENCE newsletter, your go-to source for the latest clinical data on heart diseases, diagnostics, and monitoring.

Our aim is to provide you with cutting-edge information that will keep you up to date on the most recent advancements in the field of heart failure management and sudden cardiac death prevention.

NEW: Prof Matteo Bertini’s comment on this edition of the ClinicalEVIDENCE newsletter:

Matteo Bertini, M.D, PhD, FAIAC
Professor of Cardiology, Head of EP lab, Cardiological Center, Sant’ Anna University Hospital

“ICD devices carry a higher risk of infection, particularly at the time of replacement, compared with pacemaker systems. Therefore, battery longevity is an important consideration.

Nishino et al. evaluated battery performance in ICD recipients have shown that factors such as device type, percentage of ventricular pacing, and overall system design influence longevity.

It is especially important to take battery life into account when implanting ICD or CRT-D systems in younger patients, who may require multiple replacements over their lifetime.”

Summary

This edition of Clinical Evidence features new data on the LUX-Dx™ Insertable Cardiac Monitor (ICM), ICD and CRT-D battery longevity, and the subcutaneous implantable cardioverter defibrillator (S-ICD). 

A European experience demonstrates how LUX-Dx™ remote reprogramming and alert-based strategies can enhance monitoring efficiency and reduce clinical workload. 

Analyses from Japan show that ICD and CRT-D battery life varies significantly by manufacturer, highlighting the importance of selecting devices with longer longevity to reduce complications and optimize healthcare resources. 

Data from the French HONEST registry further indicate that omitting routine S-ICD defibrillation testing maintains safety while supporting individualized patient care.

Key Takeaways

  1. Reducing clinical burden via remote ICM programming. Real-world findings¹ show that strategic LUX-Dx™ ICM reprogramming can lower transmissions, alerts, and episodes. Remote reprogramming helps ease clinical workload and reduce in-office visits.
  2. ICD and CRT-D battery longevity by manufacturer. Nishino et al.² reported significant differences in device longevity across manufacturers, highlighting the importance of selecting longer-lasting devices to reduce complications and optimise healthcare resources.
  3. Is routine defibrillation testing still needed in S-ICD? Data from the HONEST registry³ show that omitting routine defibrillation testing does not compromise safety or efficacy, supporting a more individualised approach to S-ICD implantation.

Gain deeper insights by downloading the full newsletter

Clinical EVIDENCE

Newsletter #8

Now Available in PDF Format


References:

  1. Fareh S., Nardi S., Argenziano L. et al. Real-world use of insertable cardiac monitor remote programming: A multicenter European experience Heart Rhythm O2 2025; doi 10.1016/j.hroo.2025.08.035.
  2. Nishino K, Temma T, Watanabe et al. Battery Longevity in Modern Implantable Cardioverter-Defibrillators and Cardiac Resynchronization Therapy-Defibrillators. J Arrhythm. 2025 Aug 15;41(4):e70175. doi: 10.1002/joa3.70175.
  3. Kerkouri F, Eschalier R, Fareh S, et al. Defibrillation Testing During Implantation of Subcutaneous Implantable Cardioverter Defibrillators. J Am Coll Cardiol. 2025 Jul 8;86(1):32-45. doi: 10.1016/j.jacc.2025.04.048.

CAUTION
The law restricts these devices to sale by or on the order of a physician. Indications, contraindications, warnings, and instructions for use can be found in the product labelling supplied with each device or at  www.IFU-BSCI.com. Products shown for INFORMATION purposes only and may not be approved or for sale in certain countries.
This material not intended for use in France.