SEATTLE II Trial
EKOS Endovascular System PE Clinical Studies
A Prospective, Single-Arm, Multicentre Trial of Ultrasound-Facilitated, Low-Dose Fibrinolysis for Acute Massive and Submassive Pulmonary Embolism
G. Piazza MD, MS et al, JACC Cardiovasc Interv. 2015 Aug 24; 8(10): 1382-92
25% decrease in RV/LV ratio over 48 hours.
Minimised risk of intracranial haemorrhage.
Rapidly relieved pulmonary artery obstruction.
Reduced pulmonary hypertension.
Ultrasound-facilitated, catheter-directed, low-dose fibrinolysis for acute PE improves RV function and decreases pulmonary hypertension and angiographic obstruction. By minimising the risk of intracranial bleed, it represents a potential “game-changer” in the treatment of high-risk PE patients.