Internal view of patient's torso demonstrating targeted accuracy of TheraSphere Y-90 Glass Microspheres in liver.

TheraSphere™ Y-90 Glass Microspheres


PROACTIF study overview

The largest, prospective, real-world, Y-90 study of primary liver cancer in 1,000+ patients using TheraSphere​ Y-90 Glass Microspheres.

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1,000+ patients

First multi-center, 1,000+ patient study that builds on previously published TheraSphere landmark trials which span the Barcelona Clinic Liver Cancer (BCLC) guidelines


30+ sites

Data from 30+ sites using contemporary techniques and dosing

Study objective

The study aims to gather data on effectiveness, patient quality of life (QoL), and safety with use of TheraSphere Y-90 glass microspheres in real-world clinical settings in France.

Primary endpoints

Overall survival (OS) from time of TheraSphere treatment and quality of life, as assessed by using the functional assessment of Cancer Therapy – Hepatobiliary (FACT-Hep) questionnaire.

Key secondary endpoints

Grade ≥3 AEs, SAEs, tumor response, tumor marker response, subsequent therapy, and dosimetry evaluations.

AE = Adverse event. SAE = Serious adverse event.

This study is sponsored by Boston Scientific. Final results are expected in 2025 and will include full patient population with additional information on quality of life, safety and dosimetry.

Garin E, Bailly C, Letang A et al. Abstract No. 257 • Featured Abstract The PROACTIF French Registry Study of Y-90 Glass Microspheres for the Treatment of Liver Malignancies: Interim Analysis of 670 Hepatocellular Carcinoma (HCC) Patients. J Vasc Interv Radiol. 2024 Mar 35(3):S113 doi: (updated dataset for oral presentation at SIR March 2024)

Results from different clinical investigations are not directly comparable. Information provided for educational purposes only.

The law restricts these devices to sale by or on the order of a physician. Indications, contraindications, warnings, and instructions for use can be found in the product labelling supplied with each device or at Products shown for INFORMATION purposes only and may not be approved or for sale in certain countries. This material not intended for use in France.