Physicians want to be confident that they are not deferring an ischemic lesion.
An FFR reading < 0.80 is the most often cut off used in clinical studies (FAME). To expect the outcomes of the major clinical studies (FAME, FAME II, etc.) 0.80 with maximum hyperemia should be used.
- AUC Guidelines reflect the FAME cutoff of 0.80.
What are the Benefits of FFR?
- FAME I Trial demonstrated that FFR-guided stenting (FFR < 0.80) vs. angio-guided significantly improved outcomes. Learn more
- FAME II Trial illustrated that PCI was superior to medical therapy with FFR < 0.80. Learn more
- Both FAME I and II stated FFR was economical compared to other standards of care and lowered costs within 1-year compared to angiography. Learn more
1. Tonino P, De Bruyne B, Pijls N, et al. Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention. NEJM. 2009; 360:213-224.
2. Fearon WF, Bomschein B, Tonino PA, et al. Economic evaluation of fractional flow reserve-guided percutaneous coronary intervention in patients with multivessel disease. Circulation. 2010;122(24):2545-50.