Summary
This Clinical Evidence delves into the most recent real-world data concerning the performance of the HeartLogic™ algorithm and S-ICD and their potential application in clinical practice to improve patient outcomes. A new re-validation of the HeartLogic diagnostic tool¹ is explored in order to confirm the performance of the algorithm in clinical practice for implantable cardioverter defibrillators (ICD) and cardiac resynchronization therapy devices (CRT-D). S-ICD clinical experiences from two retrospective analyses from the observational Rhythm Detect registry are described. One analysis assesses the enhanced outcomes associated with placing the S-ICD generator in the intermuscular space²; the other investigates the decrease in inappropriate therapies through device programming³.
Key Takeaways
- HeartLogic Algorithm: Real-World Validation:
HeartLogic performances were validated in a real-world setting: high performance in terms of sensitivity and false positive rate were confirmed for ICD and CRT-D patients¹. - S-ICD Performance in Real-World Practice 1:
Placing the S-ICD generator in the intermuscular space instead of the standard subcutaneous pocket results in fewer device-related complications and inappropriate shocks over a medium-term follow-up² . - S-ICD Performance in Real-World Practice 2:
In clinical practice, there has been a trend in recent years towards the wider adoption of optimized programming. The standardised programming proposed by the UNTOUCHED study reduced the rate of inappropriate shock in the S-ICD population, without affecting therapy effectiveness³.
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