POLARIS

• Results of a cost-effectiveness analysis in the United States demonstrated a reduction in MI, revascularization, and cardiac death among general CAD population treated with IVUS as compared to angiography alone.¹
  
  
• IVUS was particularly effective in high risk subgroups, specifically in patients with diabetes, ACS, and Impaired Renal Function.²
  
  
• Evidence suggests that IVUS reduces the rate of severe cardiac events at 30 days, which may result in fewer MI related readmissions. Thirty-day readmissions are measured under the US CMS readmissions reduction program.³
  
  
• Over the lifetime of a CAD patient, IVUS could potentially save a total of $2,142 as compared to angiography alone.¹
  
  
• The potential savings are even higher ($2,997, $2,879, and $3,257) when modeling patients with diabetes, ACS, and impaired renal function.¹

Adverse cardiac events are a substantial burden to the health system:

• Cost per MI: $8,039^*
  
  
• Cost per revascularization: $12,948^†

1. Ahn JM, Kang SJ, Yoon SH, et al. Meta-analysis of outcomes after intravascular ultrasound-guided versus angiography-guided drug-eluting stent implantation in 26,503 patients enrolled in three randomized trials and 14 observational studies. Am J Cardiol. 2014; 113(8), 1,338-47.

2. Wizenbichler B, Maehara A, Weisz G, Neumann FJ, et al.: Relationship between Intravascular Ultrasound Guidance and Clinical Outcomes after Drug-Eluting Stents: The Assessment of Dual Antiplatelet Therapy with Drug-Eluting Stents (ADAPT-DES) Study. Circulation. 2014; 129, 463-470.

3. Wasserman M, Priest V, Simmonds M. The long and the short of it: A comparison of ICERs for intravascular ultrasound (IVUS) using short and long-term benefit assumptions. Health Technology Assessment International Conference. 15-19 June 2013; Seoul, South Korea.

* Assumes a weighted average cost of $8,039 per MI (50% treated medically, $1,730 and 50% treated with revascularization; weighted average cost of $14,348 per revascularization (90% treated with PCI, $11,541 and 10% with CABG, $39,617); MI drug costs used calculated AWP (WAC + 20%)

† Assumes a weighted average cost of $12,948 per revascularization (90% treated with PCI, $11,541 and 10% treated with CABG, $25,612)