Multicenter Automatic Defibrillator Implantation Trial Reduce Inappropriate Therapy (MADIT-RIT)

Status: Completed in 2012

Boston Scientific is excited to provide you with the results of the MADIT RIT trial presented November 6th, 2012 during the Late Breaking session at the American Heart Association meeting in Los Angeles and published in the New England Journal of Medicine. This prospective randomized trial of 1500 patients was designed to determine if alternate (improved) programming could reduce the occurrence of inappropriate therapy (shock or ATP) in primary prevention patients with a dual-chamber ICD or CRT-D device.


In the MADIT RIT trial, when improved programming was used, patients were more likely to receive therapy only when needed.

  • The improved programming reduced the risk of inappropriate therapy by 76-79% when compared to conventional programming (p<0.001; HR=0.24;0.21 respectively).
  • Risk of death was decreased by 44-55% for patients who received the improved programming when compared to conventional programming. (p= 0.06; HR=0.56; p=0.01 HR=0.45 respectively).