Inhibition of Unnecessary RV Pacing with AV Search Hysteresis in ICDs (INTRINSIC RV)
Status: Currently enrolling patients
The largest ICD trial to date investigating whether dual-chamber rate-responsive (DDDR) with Boston Scientific’s algorithm, atrioventricular search hysteresis (AVSH) 60-130 programming is not inferior to single-chamber (VVI)–40 programming in an implantable cardioverter defibrillator (ICD) with respect to all-cause mortality and heart failure hospitalizations.
- Dual-chamber pacing with AV Search Hysteresis (AVSH) performed as well as single-chamber pacing (p<0.001 non-inferiority).
- Patients with dual-chamber pacing with AVSH had outcomes that trended better than patients with single-chamber pacing (p=0.072 superiority).
- Standard ICD indications
- No indications for bradycardia pacing
- LVEF ≤ 40%
- No history of persistent atrial arrhythmias
- Showed that dual-chamber pacing with AV Search Hysteresis performed as well as single-chamber pacing
- Represents a diverse patient population with standard ICD indications
- Perceived safety concerns were not present when appropriate dual-chamber pacing was utilized