Medical Specialties > Structural Heart > SENTINEL™ Cerebral Protection System

It only takes one piece, and it can happen to any TAVI patient.

No matter their age. No matter their background. Even minor cognitive events can represent life-changing effects for your patients and their families. So it’s time to take another look at the effects of every stroke, and reassess how we can prevent them.

Any stroke can be devastating

Any stroke can devastate your patients and their families. Even minor cognitive events can result in significant negative consequences on their quality of life.

The rates are underdiagnosed. But the effects are impossible to ignore.

The Facts of Stroke

4%

Weighted-average All-Stroke
rate across contemporary
studies, independent of
center experience, operator
volume, or patient risk score.^1-5

1/10

Post-procedure TAVI patients
show overt signs of ischemic
brain injury⁶

6x

Increase in stroke-related
30-day mortality, post-TAVI⁷

^{1. Manoharan G, et al., J Am Coll Cardiol Intv 2015; 8:1359-67. 2. Wendler O, et al., Circulation 2017; 135: 1123–1132. 3. Seeger J, et al., Eur Heart J. 2018 Dec 24. doi: 10.1093/eurheartj/ehy847. 4. Haussig S et al., JAMA 2016; 316:592–601. 5. Kapadia S, Kodali S, Makkar R, et al., Protection against cerebral embolism during transcatheter aortic valve replacement. JACC. 2017; 69(4): 367–377. 6. SENTINEL IDE Trial. Data presented at SENTINEL Advisory Panel, February 23, 2017. 7. The CENTER Collaboration. N = 10982 Patients undergoing TF-TAVR with Edwards™ balloon-expandable valves or Medtronic™ self-expanding valves between 2007-2018 from 3 national registries and 7 local registries or prospective clinical trials.}

The cost of TAVI-related stroke is meaningful

Stroke has an impact on the quality-of-life of patients, their families and caregivers. And in addition to this, patients experiencing stroke have higher costs due to hospitalization, longer LoS, hospital re-admissions, rehabilitation and social costs.

Societal Costs of Stroke

13 773€

Increased mean cost for patient & caregivers,
just in the first year after experiencing stroke⁸

^{8. Kotseva et al. Patient and caregiver productivity loss and indirect costs associated with cardiovascular events in Europe. Eur J Prev Cardiol, 2019 Jul;26(11).}