Electrophysiology / HeartLogic™ Heart Failure Diagnostic / Clinical Data / MultiSENSE

About MultiSENSE


MultiSENSE was an international, multicenter, non-randomised feasibility study designed to determine how ambulatory sensor measurements change with worsening heart failure (HF).


Develop and validate a multi-sensor algorithm for the early detection of worsening heart failure.


HeartLogic multi-sensor index and alert algorithm provide a sensitive and timely predictor of impending heart failure decompensation.1



The Journey

Icon of a piece of paper with a heartbeat going across.


  • 10+ years research
  • Data analysis from 12 clinical trials
  • Extensive HF clinic customer visits
Icon of two interlocking cogs.

Algorithm Development

  • Thousands of candidate features evaluated and down selected for optimal algorithm development
Icon of an arrow navigating through three Xs.

Algorithm Design

  • Multiple fusion techniques evaluated
  • Multiple combinations of learnings leveraged in final algorithm
MultiSENSE Study Results
The MultiSENSE study assessed more than 900 patients and validated the HeartLogic algorithm to have:1
Icon of a heart.


in Detecting Heart Failure Events

Icon of a calendar.


Advance Notice of Worsening Heart Failure

Icon of an exclamation point inside a triangle.


Per Patient Per Year

Chart showing the HeartLogic sensitivity and unexplained alert rates per patient-year.
Physician Perspectives

“From the time an alert occurs until the heart failure event—the median time is 34 days. That gives us a great opportunity to change the course of the future.”

John P. Boehmer, MD

Identifying High-Risk Patients

The MultiSENSE study demonstrated HeartLogic Heart Failure Diagnostic’s ability to identify high-risk patients, which may allow clinicians to focus on patients at highest risk while maintaining surveillance of low-risk patients.

Read the Article
A Multisensor Algorithm Predicts Heart Failure Events in Patients With Implanted Devices: Results From the MultiSENSE Study

Stay Up To Date
Sign up for periodic emails and receive a HeartLogic fact sheet to share with your patients’ care teams.
Electrophysiology Insights
Find out how HeartLogic helps you see patients’ physiologic responses to arrhythmic and pacing changes.
Get Phase I results from this global trial evaluating the integration of HeartLogic into clinical practice.