SmartDelay determined AV Optimization: A Comparison of AV Optimization Methods Used in Cardiac Resynchronization Therapy (SMART-AV)
Status: Completed in 2010
- The change in LVESV for the SmartDelay arm was no different than echocardiographic determined AV interval optimization as well as a Fixed AV delay of 120ms.
- Echo was not superior to a fixed AV delay.
For additional information, please see the manuscript published in Circulation
- Eligible study participants included both male and female patients over 18 years of age whose disease state at the time of enrollment met indications for CRT-D therapy.
- 1060 patients were enrolled at 100 sites across the United States and Europe.
- To assess the chronic effects of three methods for determining AV delay timing during CRT: EGM optimization, echo optimization, and fixed
- Primary Endpoint: LVESV
- Secondary endpoints include: 6-minute walk, NYHA Class, and QOL
- SMART-AV is the first large scale trial to compare methods of optimizing AV delay, evaluate if more frequent re-optimization can improve clinical outcomes, and assess whether acute benefits translate into chronic benefits.