Resynchonization Therapy Trials and Studies
SmartDelay determined AV Optimization: A Comparison of AV Optimization Methods Used in Cardiac Resynchronization Therapy (SMART-AV)
SMART-AV is the first large-scale trial to compare methods of optimizing AV delay, evaluate if more frequent re-optimization can improve clinical outcomes, and assess whether acute benefits translate into chronic benefits.
The Multicenter Automatic Defibrillator Implantation Trial – Cardiac Resynchronization Therapy (MADIT-CRT)
MADIT CRT is a randomized study, designed to determine whether prophylactic CRT in combination with an ICD would reduce the risk of death or nonfatal heart-failure events (whichever came first),as compared with patients receiving only an ICD. MADIT-CRT provides clinical evidence that in high-risk* NYHA Class I and II patients with LBBB, early CRT intervention reduces the relative risk of all-cause mortality or first heart failure event by 57% when compared to ICD therapy (p < 0.001).1
The Multicenter Automatic Defibrillator Implantation Trial – Cardiac Resynchronization Therapy (MADIT-CRT) Long Term Follow-Up
The MADIT-CRT long term trial showed that treatment with CRT-D was associated with a 34% relative reduction in the risk of nonfatal heart-failure events or death from any cause, as compared with implantable cardioverter–defibrillator (ICD) therapy alone over a median follow-up period of 2.4 years.