A Catheter-Based Approach to Treat Uncontrolled Hypertension
Renal denervation is an emerging, minimally-invasive, catheter-based approach to treat uncontrolled hypertension. The kidney plays a vital role in the regulation of blood pressure and renal nerve hyperactivity has been demonstrated to be a major factor in hypertension.
Renal denervation uses radiofrequency (RF) energy to selectively target and disrupt the renal sympathetic nerves whose hyperactivity leads to hypertension. Clinical evidence has shown renal denervation to have a favorable safety profile and a substantial and presumably sustained blood pressure reduction.
Hypertension is a global epidemic, affecting nearly a billion people worldwide1 and more than a quarter of all adults. This condition is a major risk factor for a variety of cardiovascular diseases, including coronary artery disease, heart failure, stroke and peripheral vascular disease. Hypertension accounts for an estimated 54 percent of all strokes and 47 percent of all ischemic heart disease globally2.
Most in the medical community agree that hypertension is multifactorial in nature and requires multiple therapeutic approaches targeting the underlying aspects of the disease. All major guidelines promote a combination of lifestyle modification and treatment with antihypertensive medications to reach target blood pressure levels. Although this approach works for many, it fails in a considerable number of patients for various reasons including drug-intolerance and non-compliance, leaving their blood pressure high and uncontrolled. It is estimated that 45% - 81% of patients with hypertension have uncontrolled hypertension3, leaving them at unacceptably high cardiovascular risk.