POLARIS

Multi-Modality Guidance System

What is Pd/Pa?

Pd/Pa calculates the entire cardiac cycle at rest.

Pd/Pa = iFR, like °C = °F

“Pd/Pa seems to offer a universal resting physiological metric with equivalent agreement to iFR. Although not numerically identical, 1 index can be linearly transformed into the other, much like the conversion of units of temperature. Using the binary cutoff of iFR ≤0.89 as a reference standard, Pd/Pa showed excellent agreement according to ROC curve analysis and the best cutoff value of Pd/Pa was ≤0.91.”

-Kobayashi Y, et al. JACC Oct 2017.

How do Pd/Pa and iFR compare?

Unlike iFR and FFR which only contain 66% of the same information, Pd/Pa and iFR contain 95% of the same information. Therefore, a Pd/Pa cutoff of 0.91 = an iFR cutoff of 0.89 as shown in Resolve, Verify 2 and Kobayashi et al.1,2

Pd/Pa and iFR contain 95% of the same information

 
 

Pd/Pa

iFR

Single Cutoff3

≤0.91

≤0.89

Hybrid Algorithm4,5

0.88-0.97

0.86-0.93

FDA-Cleared6

Inclusion in Appropriate Use Criteria7,8

SCAI/ACC Reimbursement Recommendation9

Equivalent Correlation to FFR10,11,12,13

Equivalent Correlation to CFR14

Results Integrate into All Major Hemodynamic Systems

X

ECG-free Algorithm Widely Available15

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Workhorse Pressure Guidewires Available

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