POLARIS

Multi-Modality Guidance System

DFR™ Diastolic Hyperemia-Free Ratio™*

Pooled Analysis from VERIFY 2 and CONTRAST Showed: DFR and iFR™ were Numerically Identical

Methodology of DFR Analysis1
Boston Scientific’s Diastolic Pressure Ratio (dPR) Definition

  • DFR values were compared to iFR values using the 893 waveform tracings from the 833 patients pooled from the VERIFY 2 and CONTRAST studies
  • The DFR window uses two criteria: Pa < mean Pa and down-sloping Pa
  • No ECG signal were required
  • No need to identify dicrotic notch

Intermediate Lesion1

dPR: 0.90
iFR: 0.90
Intermediate Lesion

Severe Lesion1

dPR: 0.71
iFR: 0.71
Severe Lesion
5-beat average in bold = DFR definition

DFR coming soon to the POLARIS Multi-Modality Guidance System

Class Effect Among Resting Indices

Class Effect Among Non-Hyperemic Pressure Ratios

Watch Prof. Keith Oldroyd, Dr. Ziad Ali, and Dr. Luis Raposo discuss the class effect among all resting indices on PCRTV. Learn about new options in non-hyperemic pressure ratios, including dPR, that were presented at EuroPCR and why measuring different parts of diastole yields numerically identical results to iFR.

 

Pooled Analysis Output: DFR Shown to be as Accurate to iFR as Two iFR Measurements were to Each Other

DFR values were compared to iFR values using the 893 waveform tracings from the 833 patients pooled from the VERIFY 2 and CONTRAST studies1

VERIFY 2 + CONTRAST Pooled Analysis: DFR Showed Equivalency to iFR

VERIFY 2 Analysis: DFR Shown to be within the Intra-iFR Variation of ~0.01

Further Proof of Concept: Measuring Different Parts of Diastole Yields Numerically Identical Results Using the 0.89 Cutoff

30% of Diastole

dPR: 0.86
iFR: 0.86
30% of Diastole

65% of Diastole

dPR: 0.86
iFR: 0.86
65% of Diastole

90% of Diastole

dPR: 0.86
iFR: 0.86
90% of Diastole

dPR = iFR - 6 Definitions of Proof2,3

Selecting the wave-free period is not necessary for calculating results numerically identical to iFR.

COMPARISON OF DIFFERENT DIASTOLIC RESTING INDEXES TO IFR2

Read the latest JACC publication that compares different diastolic resting indexes to iFR and learn why all diastolic resting indexes tested were identical to iFR, both numerically and with respect to their agreement with FFR. 

Evolution of Resting Physiology with Nils P. Johnson

Evolution of Resting Physiology

Watch Nils P. Johnson, MD at CRT18 discuss the history of resting physiology including an overview and comparison of diastolic pressure ratios (dPR) with iFR and Pd/Pa.

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