MADIT

Multicenter Automatic Defibrillator Implantation Trial (MADIT)

Status: Completed in 1996

The clinical trial that established for the first time that patients no longer have to experience a life-threatening arrhythmia to qualify for and receive the lifesaving benefits of ICD therapy.


Results

Design

Two patient groups (1:1)
1. Conventional Medical Therapy (CMT)
2. CMT + ICD

Primary endpoint: Mortality

Patient Population

  • Heart attack survivors:
  • Prior MI
  • EF ≤ 35%
  • Asymptomatic NSVT
  • NYHA Class I-III

196 patients from 32 U.S. centers

  • 95 received defibrillator
  • 101 received medical therapy 

Clinical Relevance

  • Established for the first time that prophylactic ICD therapy used in conjunction with conventional medical therapy can dramatically improve survival in high-risk patients versus conventional medical therapy alone
  • Patients no longer have to experience a life-threatening arrhythmia to qualify for and receive the lifesaving benefits of ICD therapy 

Top