Resynchonization Therapy Trials and Studies

SABA Study

Battery Longevity in Cardiac Resynchronization Therapy Implantable Cardioverter Defibrillators was released online in October 2013 by EP EuroPace and is the first independent, head-to-head, retrospective study comparing battery longevity of contemporary cardiac resynchronization therapy defibrillators (CRT-Ds).

SmartDelay determined AV Optimization: A Comparison of AV Optimization Methods Used in Cardiac Resynchronization Therapy (SMART-AV)

SMART-AV is the first large-scale trial to compare methods of optimizing AV delay, evaluate if more frequent re-optimization can improve clinical outcomes, and assess whether acute benefits translate into chronic benefits.

Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure (COMPANION)

COMPANION is the first trial to show that Cardiac Resynchronization Therapy, used in combination with Optimal Pharmacologic Therapy, can significantly improve both the quality and duration of life for a large group of heart failure patients.


The first study to demonstrate the benefits of CRT combined with ICD therapy, enabling a single device to treat two clinical outcomes common to patients with advanced heart failure.