INTRINSIC RV

Inhibition of Unnecessary RV Pacing with AV Search Hysteresis in ICDs (INTRINSIC RV)

Status: Currently enrolling patients

The largest ICD trial to date investigating whether dual-chamber rate-responsive (DDDR) with Boston Scientific’s algorithm, atrioventricular search hysteresis (AVSH) 60-130 programming is not inferior to single-chamber (VVI)–40 programming in an implantable cardioverter defibrillator (ICD) with respect to all-cause mortality and heart failure hospitalizations.


Results1

  • Dual-chamber pacing with AV Search Hysteresis (AVSH) performed as well as single-chamber pacing (p<0.001 non-inferiority).
  • Patients with dual-chamber pacing with AVSH had outcomes that trended better than patients with single-chamber pacing (p=0.072 superiority). 

Design

Patient Population

  • Standard ICD indications
  • No indications for bradycardia pacing
  • LVEF ≤ 40%
  • No history of persistent atrial arrhythmias  

Clinical Relevance

  • Showed that dual-chamber pacing with AV Search Hysteresis performed as well as single-chamber pacing
  • Represents a diverse patient population with standard ICD indications
  • Perceived safety concerns were not present when appropriate dual-chamber pacing was utilized

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