Bradyarrhythmia Trials and Studies
Inhibition of Unnecessary RV Pacing with AV Search Hysteresis in ICDs (INTRINSIC RV)
The largest ICD trial to date investigating whether dual-chamber rate-responsive (DDDR) with Boston Scientific’s algorithm, atrioventricular search hysteresis (AVSH) 60-130 programming is not inferior to single-chamber (VVI)–40 programming in an implantable cardioverter defibrillator (ICD) with respect to all-cause mortality and heart failure hospitalizations.
Assessment of Proper Physiologic Response with Rate Adaptive Pacing Driven by Minute Ventilation or Accelerometer (APPROPRIATE)
This study will evaluate Boston Scientific’s Minute Ventilation (MV) sensor compared to the accelerometer (XL) sensor for superiority in providing appropriate heart rate response in pacemaker patients that are chronotropically incompetent.
Restoration of Chronotropic Competence in Heart Failure Patients with Normal Ejection Fraction (RESET)
RESET is a pioneering effort that is exploring a device-based therapy solution for a population of heart failure (HF) patients with a preserved or normal EF, who currently have limited treatment options.