Agent™

Paclitaxel Coated-PTCA Balloon Catheter

The Agent™ Paclitaxel Drug Coated Balloon catheter, with its innovative TransPax™ coating technology1, provides a targeted, therapeutic dose of proven, anti-proliferative Paclitaxel to the lesion2. It was designed to minimise downstream particulates while maintaining the outstanding deliverability you’ve come to expect with Boston Scientific products3

Key Resources

Agent Drug Coated Balloon Brochure Agent Drug Coated Balloon Spec sheet

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Product Details

 

The Agent™ Paclitaxel-Coated balloon catheter, built on the Emerge™ PTCA Balloon Catheter for exceptional deliverabilityr, is indicated for Percutaneous Transluminal Coronary Angioplasty (PTCA) in the coronary arteries to treat in-stent restenosis (ISR) and de novo / small vessel disease.

Optimal dose of 2µg/mm2 compared to 3µg/mm2 of market leading DCBs efficiently achieves sustained benefits of Paclitaxel2 over time.

What is TransPax™

 

The TransPax coating is a proprietary formulation of Paclitaxel and a citrate ester excipient (acetyl tributyl citrate – ATBC). It leverages Boston Scientific’s history and expertise with paclitaxel and drug coating.

Boston Scientific’s TransPax™ is the coating on both IC and PI Drug-coated balloons (DCB). Ranger™ Paclitaxel-Coated PTA Balloon Catheter is Boston Scientific's DCB for Peripheral Interventions.

 

The TransPax drug coating is a proprietary formulation of Paclitaxel and a citrate ester excipient (ATBC) The TransPax drug coating is a proprietary formulation of Paclitaxel and a citrate ester excipient (ATBC)

What is the Delivery System

Agent™ Drug-Coated Balloon is built on the Emerge™ balloon catheter technology which combines the best of Boston Scientific balloon technologies to offer exceptional deliverability5 with an ultra-low tip profile and is designed to navigate and cross even the most challenging lesions with unprecedented ease.

Design of the catheter of Agent Paclitaxel-Coated PTCA Balloon Design of the catheter of Agent Paclitaxel-Coated PTCA Balloon

 

Agent Infographic

History

History for Paclitaxel on cardiovascular space History for Paclitaxel on cardiovascular space

How it works*

Once the DCB has been deployed, the durable TransPax coating:

1. Ensures that a consistent drug dose is delivered to a lesion*

2. Binds with microtubules to inhibit proliferation of smooth-muscle cells*

3. Enables healing by selectively impacting cells that cause restenosis while allowing healing of endothelial cells*

Infographic of TransPax Coating Technology Infographic of TransPax Coating Technology

Safety and performance*

Enhanced Coating Integrity Enhanced Coating Integrity

Enhanced Coating Integrity*

Designed to improve coating durability and drug transfer efficacy, allowing for a lower dosage of Paclitaxel*

Optimized Drug Transfer Optimized Drug Transfer

Optimized Drug Transfer°

Balanced hydrophobic and hydrophilic properties allow efficient drug transfer to the vessel wall

Minimized Systemic Loss Minimized Systemic Loss

Minimized Systemic Loss§

Less particulates and systemic loss while optimizing arterial tissue Paclitaxel levels.

* Drug coating designed to deliver therapeutic drug dose in association with balloon angioplasty treatment. Data on file at Boston Scientific.
° Data on file at Boston Scientific. Pre-clinical results may not be necessarily indicative of clinical outcomes.
§ Bench testing performed by Boston Scientific. Results not necessarily indicative of clinical performance.

Compliance Chart

AGENT compliance chart AGENT compliance chart

Ordering Information

Balloon Length

Ø(mm) 12mm 15mm 20mm 30mm
2.00 H74939222201210 H74939222201510 H74939222202010 H74939222203010
2.25 H74939222221210 H74939222221510 H74939222222010 H74939222223010
2.50 H74939222251210 H74939222251510 H74939222252010 H74939222253010
2.75 H74939222271210 H74939222271510 H74939222272010 H74939222273010
3.00 H74939222301210 H74939222301510 H74939222302010 H74939222303010
3.50 H74939222351210 H74939222351510 H74939222352010 H74939222353010
4.00 H74939222401210 H74939222401510 H74939222402010 H74939222403010

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