Doxorubicin (DX) is cytotoxic, embryotoxic, carcinogenic, teratogenic, and mutagenic
(Working with Doxorubicin - VCU Office of Environmental Health & Safety)
Dose of chemotherapeutic agent used in an embolisation procedure might vary from 50mg to 150mg per patient
Embozene TANDEM™ loading capacity
Comments and comparisons with DC Bead and DC BEAD M1 are made to date by BSC based on information provided by Biocompatible in the DFU and Loading Instructions available on BTG website. Comments and comparisons with Hepasphere are made to date by BSC based on information provided by Merit Medical in the DFU and Loading Instructions available on Merit Medical website. Comments and comparisons with LifePearl are made by BSC based on information provided in Interventional News.
TANDEM can load 50mg/ml or the 150mg maximum dose by patient in a single 3ml syringe instead of 2ml container.
Results from a meta-analysis of the pertinent literature were used to construct a CE Markov simulation model which followed a hypothetical cohort of HCC patients who underwent DEB-TACE or cTACE, covering the entire post-TACE lifespan until death. Costs were assessed from the health-care provider perspective.
Dig Liver Dis. 2016 Jul;48(7):798-805.
DEB-TACE was found more cost-effective than cTACE when a minimum willingness-to-pay of about 2.000–3500€/QALY was accepted, mainly depending on shorter in-hospital stay and better quality of life.
A new treatment is considered more cost-effective than the competing one when the ICER remains below of the WTP threshold of US$50,000 (around €44,000) .
The mean and median of Incremental Cost Effectiveness Ratio (ICER) calculated for cancer-specific drug intervention was $138.582/QALY and $55.500/ QALY, respectively, compared with $49.913/QALY and $31.000/QALY, respectively, for non cancer drugs.
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