ALTITUDE SM


ALTITUDE Clinical Science ProgramStatus: Ongoing

 

The ALTITUDE clinical science program is analyzing comprehensive data from the LATITUDE® Patient Management system to provide insight into meaningful questions related to implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy defibrillator (CRT-D) therapy. The ALTITUDE program is managed in collaboration with an external physician panel of thought leaders who assist in identifying relevant clinical issues for analysis.

Boston Scientific has enrolled over 150,000 patients on the LATITUDE system since its introduction in 2006. The database has had over 7 million transmissions, making it a very large source of data from a non-selected patient population that is 20 times the enrollment of most clinical trials.

The LATITUDE system allows physicians to schedule remote follow-ups of implantable cardiac devices to monitor specific device information and patient heart health status. It can also detect clinical events physicians.

 


 

Results

 

Presented Abstracts

ACC 2011

ALTITUDE ACC 2011 Abstracts

  • Atrial Pacing Frequency and Mortality in CRT Recipients:
    Results from the ALTITUDE Study Group
  • Atrial Fibrillation and Outcomes in a Large Cohort of CRT Recipients:
    Results from the ALTITUDE Study

 :

HRS 2011

ALTITUDE HRS 2011 Abstracts


HRS 2010

HRS 2009

  • Survival After ICD and CRT-D Implant in A Large Cohort of Heart Failure Patients Treated with Contemporary Drug and Device Therapies -Results of the ALTITUDE Study - ALTITUDE Late-Breaker  

Users can view this abstract by visiting the following website URL: http://www.hrsonline.org/Sessions/ScientificProgram/late_breaking.cfm

 

  • Percent Biventricular Pacing Impacts Mortality in Heart Failure Patients
  • Right Ventricular Pacing Impacts Mortality in a Large Cohort of ICD Recipients


HFSA 2009

  • The Relationship of the LATITUDE Patient Symptom Report to Heart Failure Hospitalization


AHA 2009

  • Home Blood Pressure Monitoring Provides Important Prognostic Information in Patients Treated with a Cardiac Resynchronization Therapy Defibrillator


HRS 2008

  • Shock Incidence and Device Programming in the LATITUDE Patient Cohort
  • Do Acute changes in Blood Pressure Predict an Atrial Tachycardia Response (ATR) Episode
  • The Relationship of Heart Failure and Atrial Arrhythmias as Measured by Acute Changes in Weight and Atrial Tachycardia Response (ATR) Episodes
  • Performance of the Medtronic Sprint Fidelis® Lead on the LATITUDE Patient Network
  • Atrial high rate episodes of Varying Durations Across Time in the LATITUDE Patient Cohort


HFSA 2008

  • Durability of Weight and Blood Pressure Measurement Compliance Using an Internet-Based Patient Management System


AHA 2008

  • Is Latitude Remote ICD Follow up Associated with a Reduced Mortality?

 

 

Design

  • The ALTITUDE clinical science program benefits physicians by enhancing their understanding of device therapy, outcomes, and disease progression in the real-world device patients connected by LATITUDE.  
  • The ALTITUDE program is managed in collaboration with an external physician panel who assists in identifying relevant clinical issues for analysis. 

 

Patient Population

  • ALTITUDE is a retrospective, non-randomized, postmarket analysis of real-world data from the over 150,000 patients enrolled in the LATITUDE Patient Management system.    
  • The ALTITUDE program is managed in collaboration with an external physician panel who assist in identifying relevant clinical issues and patient populations for analysis.

 

Clinical Relevance

 

  • The ALTITUDE project will evaluate patterns of use, incidence of events, and the application of device therapy from LATITUDE to answer clinical and epidemiological questions related to understanding CRM device therapy in real-world practice.
  • JIF# CRM6-3601-0210

 

In the News

The ALTITUDE Survival Study, which analyzed long term patient outcomes and the influence of remote device follow-up on over 194,000 patients, was recently published in the Dec 7th issue of Circulation.

  Click here to access a copy of the manuscript

 

Downloadable Resource

Download slide deck for the ALTITUDE Study

PowerPoint Image  ALTITUDE Study Slides (PPT)

 

ALTITUDE Physician Panel

External physician panel of thought leaders who assist in identifying relevant clinical issues for analysis

  Physician Panel

 

ALTITUDE Bibliography to date

Reference listing available for all LATITUDE publications to date since 2008

  Physician Panel

 

Important Safety Information

 

1 - Analysis of aggregate limited data-set from LATITUDE Patient Management System data as of 6/08/09. Data on file.

CRM10-1525-0811

DAS0008-52 & 0012-36 

TRUSTe European Safe Harbor certification